To solubilise something means to make it dissolve in a liquid.
Solubilising something is usually a good thing, especially in science or cooking.
Examples:
I will solubilise the sugar in the water.
She solubilises the salt in the soup.
The scientist solubilises the powder in the liquid.
If you solubilise the medicine in the water, it will be easier to drink.
He can solubilise anything in his special liquid!
The magic potion solubilises the metal and turns it into gold.